Effect of Oxy cephalosporin on Inflammatory Factor and Immune Function in Patients with Spinal Injury Complicated with Pulmonary Infection

  • Xiaodan Lv
Keywords: Oxycephalosporin; Spinal injury with pulmonary infection; Clinical efficacy; Inflammatory factors; Immune function

Abstract

This paperanalyse the clinical effect of oxycephalosporin on spinal injury complicated with pulmonary infection and its effect on inflammatory factors and immune function. 98 patients were divided into study group and control group according to random number table method, 49 cases in each group. Patients in the control group were routinely treated with ceftriaxone sodium, cefazolin and other antibiotics, while those in the study group were treated with laxycephalosporin for 7 to 10 days. The clinical efficacy, improvement time of clinical symptoms and occurrence of adverse reactions were observed. The changes of inflammatory factors (TNF-alpha, CRP, PCT) and immune function (CD3+, CD4+, CD8+, CD4+/CD8+) were compared between the two groups before and after treatment. After treatment, the total effective rate of the study group was 97.96% significantly higher than 87.75% of the control group (P < 0.05); the improvement time of fever, cough and sputum in the study group was significantly earlier than that in the control group, with statistical significance (P < 0.05); after treatment, the levels of TNF-a, CRP and PCT in the study group were significantly lower than those in the control group, with statistical significance. After treatment, the levels of CD3+, CD4+, CD4+/CD8+ in the study group were significantly higher than those in the control group, and the levels of CD8+ were significantly lower than those in the control group (P < 0.05); nausea, vomiting and diarrhea occurred in 1 case in the control group, and drug fever occurred in 2 cases in the study group, which was alleviated after symptomatic treatment, with no significant difference (P > 0.05). Oxycephalosporin can improve the clinical efficacy of patients with spinal injury combined with pulmonary infection, improve clinical symptoms and reduce the incidence of adverse reactions, which may be related to alleviating inflammatory symptoms and improving immune function.

Published
2019-09-01