Effect of Sufentanil Preconditioning on Hemodynamics, Serum Troponin and Creatine Kinase Isoenzymes in Patients with Hypertension of Brachial Plexus Block

  • Liya Yu
Keywords: Sufentanil; Brachial plexus block; Serum troponin; Creatine kinase isoenzymes

Abstract

To investigate the effect of sufentanil preconditioning on hemodynamics, serum troponin and creatine kinase isoenzymes in patients with hypertension of brachial plexus block. 80 cases of hypertensive patients undergoing selective brachial plexus block anesthesia treated in Cardiology Department of our hospital from January 2015 to June 2017 were selected and equally divided into two groups. The observation group was given sufentanil 0.2ng/kg, while the control group received the equal volume of sodium chloride solution. The heart rate (HR) and mean arterial pressure (MAP) had no difference between the two groups at each time point (P>0.05). Serum cardiac troponin I (cTnI) and Creatine Kinase isoenzymes-MB (CK-MB) concentrations at T5 were significantly higher than those at T1 (P<0.05), no difference was found between groups at T0(P>0.05). At T5, the serum cTnI and CK-MB concentrations in the observation group were lower than those of the control group (P<0.05); The VAS scores of the observation group were lower than those of the control group at the post-anesthesia 1h, postoperative 4h, 8h, 12h, 24h, suggesting that the analgesia duration was longer in the observation group than in the control group, with statistic difference (P<0.05). Pretreatment with sufentanil can reduce serum cTnI and CK-MB levels while maintaining stable hemodynamics for hypertensive patients undergoing selective brachial plexus block anesthesia, which can effectively reduce the pain degree and exist a protective effect.

Published
2019-09-01