Effect of Low-dose Dopamine combined with Dobutamine on Serum Inflammatory Factors and Immune Function in Children with Severe Pneumonia

  • Gong Xiangying
Keywords: Low-dose dopamine; Dobutamine; Severe pneumonia in children;Serum inflammatory factors

Abstract

To explore the effect of low dose dopamine combined with dobutamine on serum inflammatory factors and immune function in children with severe pneumonia. The control group received routine treatment only. The observation group was treated with dopamine and dobutamine on the basis of routine treatment. After 3 weeks of treatment, the changes of related indicators in the two groups were evaluated. A total of 100 patients (50 in the observation group and 50 in the control group) were observed and evaluated. The total effective rate of the observation group was 96.00% (48/50), and the total effective rate of the control group was 82.00% (41/50). The difference between the two groups was statistically significant (P=0.03); the two groups were IL-6, CRP and TNF-¦Á levels were significantly lower after treatment, and the level of the observation group was significantly lower than that of the control group, the difference was statistically significant (P<0.05); the IgG, IgM, IgA levels in the two groups were significantly elevated after treatment, and the observation group The level of the index after treatment was significantly higher than that of the control group (P<0.05). The level of MMP9 and MMP9/TIMP1 in the observation group was significantly lower than that in the control group, and the level of TIMP1 in the observation group was significantly higher than that in the control group. P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups [18.00% (9/50) vs 14.00% (7/50), P=0.59]. Low-dose dopamine combined with dobutamine in the treatment of severe pneumonia in children can reduce the level of serum inflammatory factors and improve the level of immune function, thereby improving the clinical efficacy.

Published
2019-09-01