Effect of Meropenem on Th Cell Subsets, Oxygenation Index and Serological Markers in Patients with Severe Abdominal Infection

  • Ju Lin
Keywords: Meropenem; SIAI; Th cell subsets; OI;Serological markers


This paper investigates the effect of meropenem on Th cell subsets, oxygenation index (OI) and serological markers in patients with severe abdominal infection (SIAI). 56 cases of SICI patients treated in our hospital from December 2016 to December 2018 were selected and divided into two groups, namely control group (Ceftriaxone sodium + metronidazole) and study group (meropenem), each with 28 cases. Then the clinical efficacy, adverse reactions, as well as various indicators including, oxygenation index, vital signs including systolic blood pressure (SBP), body temperature, respiratory rate, diastolic blood pressure (DBP), heart rate; blood routine and blood biochemical indicators, including Hb, WBC, PLT, PCT, CRP, LA; and the levels of Th cell subsets including CD3+, CD4+, CD4+/CD8+. The total effective rate of the study group was significantly higher than that of the control group (92.86% vs 67.86%, P<0.05). The incidence of adverse reactions between the two groups had no difference (P>0.05).After treatment, the heart rate, respiratory rate, body temperature, SBP, CD3+, CD4+, CD4+/CD8+, OI, WBC, CRP, PCT, LA, Hb, PLT were significantly different from those before treatment between the two groups (P<0.05);After treatment, the CD3+, CD4+, CD4+/CD8+ and OI of the study group were significantly higher than the control group (P<0.05). The heart rate, body temperature, WBC, CRP and PCT of the study group were significantly lower than the control group after treatment (P<0.05).The application of meropenem can effectively and safely ameliorate the oxygenation index, immune function, and serum levels for SICI patients.