Effect of Combination Aspirin and Clopidogrel on Postoperative Platelet Aggregation Rate, Venous Bridge and Anastomotic Patency Rate in Patients underwent OPCAB
A retrospective study was conducted to compare the effect of aspirin alone or aspirin plus clopidogrel on postoperative platelet aggregation rate, venous bridge and anastomosis patency rate in patients underwent off-pump Coronary Artery Bypass Graft (OPCAB). 120 patients underwent OPCAB for the first time in our hospital from June 2017 to July 2018 were selected and divided into control group and observation group, with 60 cases in each group. The observation group was treated with aspirin alone, and the observation group was treated with aspirin and clopidogrel. The changes of coagulation function, flow rate, percentage of neutrophils, platelet aggregation rate, venous bridge and anastomosis patency rate were compared between the two groups. At 10 days after operation, there was no significant difference between the observation group and the control group in the amount of drainage, the coagulation function, the number of platelets and the percentage of neutrophils (P> 0.05); Platelet aggregation rate in observation group was significantly lower than that in control group (P< 0.05); The patency rate of Fitzgibbon A venous bridge in the observation group was higher than that in the control group (P< 0.05); The Fitzgibbon A anastomosis patency in the observation group was significantly higher than that in the control group (P< 0.05). The combination of aspirin and clopidogrel for patients underwent OPCAB is an effective and safe way in inhibiting platelet aggregation, reducing thrombus formation, and improving the patency rate of venous bridge and anastomosis.