Ursodeoxycholic Acid combined with TCM Liquid in the Treatment of Intrahepatic Cholestasis of Pregnancy and Its Effect on Blood Biochemical Indexes and Pregnancy Outcome

  • Yaning Chen
Keywords: Ursodeoxycholic acid; Yinzhihuang oral liquid; Intrahepatic cholestasis of pregnancy; Therapeutic effect; Blood biochemical indicators; Pregnancy outcome

Abstract

This paper explores the effect of ursodeoxycholic acid combined with Yinzhihuang oral liquid on intrahepatic cholestasis of pregnancy (ICP) and its influence on blood biochemical indexes and pregnancy outcome. Eighty-six patients with ICP in obstetrics and Gynecology Department of our hospital from September 2015 to November 2018 were randomly divided into study group and control group with 43 cases in each group according to random number table method. The control group was treated with ursodeoxycholic acid capsule, and the study group was treated with Yinzhihuang oral liquid on the basis of the control group. Both groups were treated continuously for one month. The clinical efficacy, itching symptom score, serum total bile acid (TBA), total bilirubin (TBIL), direct bilirubin (DBIL), alanine aminotransferase (GPT), glutamic oxaloacetic aminotransferase (GOT) and pregnancy outcomes were observed before and after treatment. After treatment, the total effective rate of the study group was 95.34%, which was significantly higher than that of the control group (81.39%). The itching symptom score, TBA, TBIL, DBIL, GPT and GOT levels in the study group were significantly lower than those before treatment, and were significantly lower than those in the control group (P < 0.05). Premature birth rate, cesarean section rate, amniotic fluid contamination rate, fetal distress rate and neonatal birth weight in the study group were significantly better than those in the control group (P < 0.05). Ursodeoxycholic acid combined with Yinzhihuang oral liquid is effective in the treatment of ICP patients. It can improve clinical symptoms, reduce the levels of TBA, TBIL, DBIL, GPT and GOT in ICP patients, and improve pregnancy outcomes.

Published
2019-09-01