Effect Comparison of Yasmin and Diane-35 on Lipid Metabolism and Serum Hormone Levels in Treating Polycystic Ovary Syndrome

  • Ying Shi
Keywords: Yasmin; Diane-35; PCOS; Lipid metabolism; Serum hormone


This paper compares the effect of Yasmin and Diane-35 on lipid metabolism and serum hormone levels in treating polycystic ovary syndrome (PCOS). 206 cases of PCOS patients admitted to our hospital from February 2017 to February 2019 were selected and divided into two groups according to the random number table, namely Yasmin group (n=103) and Diane-35 group (n=103). Taking 21d as a cycle, patients received the Yasmin or Diane-35 once a day for 6 cycles since the 5th day of menstruation. The pre- and post- treatment blood lipids and serum hormone levels of the peripheral fasting blood were detected. The ovarian size and follicles number were also recorded through abdominal ultrasonography. The weight of Diane-35 group was better than that of the Yasmin group, while no difference was found in BMI, scores of axillary hair and acne (P>0.05). The levels of TC, TG, LDL-C, and HDL-C of Diane-35 group were better than those of the Yasmin group (P<0.05), while the HDL-C level was higher in the Yasmin group than in the Diane-35 group (P<0.05). Diane-35 group had higher levels of LH, LH/FSH, PRL, and FIN as well as lower level of E2 than those of the Yasmin group (P<0.05), while the T level had no difference (P>0.05). The post-treatment ovarian size and follicles number between groups had no difference (P>0.05).Yasmin and Diane-35 have similar effect forhyperandrogenism amelioration for PCOS patients, while the Yasmin has the advantages of better amelioration on the serum hormone levels and blood lipid levels. Moreover, the adverse drug reactions are existed but tolerated.