Clinical Effect of Donepezil Combined with Recall Therapy on Cognitive Impairment in Patients with Alzheimer's Disease

  • Erfang Yang
Keywords: Donepezil; Cognitive impairment; Alzheimer's disease; cAMP/PKA signal

Abstract

This article analyzed the clinical effects of donepezil combined with observational therapy on cognitive impairment in patients with Alzheimer's disease. Seventy patients with Alzheimer's disease were selected and randomly divided into observation group and control group.The patients in both groups were given donepezil hydrochloride orally, 5 mg each time, once a day. The observation group added memory therapy on the basis of the control group to strengthen communication with patients and increase their trust. The two groups of patients were scored before and after treatment using the Simple Intelligence State Scale (MMSE), the Activity of Daily Living Capacity Scale (ADL), and the Total Recession Scale (GDS).The results showed that there was no significant difference in the MMSE, ADL, GDS scores between the observation group and the control group before treatment (P>0.05). The MMSE, ADL, and GDS scores in the observation group were compared with those in the control group. Statistically significant (P < 0.05).Conclusion: Donepezil can significantly increase the concentration of acetylcholine in the synaptic cleft and improve the cholinergic function in the brain. At the same time, recall therapy can improve the cognitive dysfunction of patients with Alzheimer's disease to a certain extent, reduce the anxiety caused by the disease, and it is worthy of clinical application.

Published
2019-10-01