Cerebral Protection of Oxycodone Injection in Patients with Carotid Endarterectomy
As a synthetic new opioid, oxycodone has the characteristics of rapid onset, high bioavailability and less adverse reactions. It is widely used in postoperative analgesia, but whether it can alleviate postoperative brain damage in patients. To be studied.This article investigated the protective effects of oxycodone preconditioning on carotid endarterectomy in patients. Sixty patients with CPB descending carotid endarterectomy were randomly divided into 4 groups: control group and different doses of oxycodone. In the different doses of oxycodone group, oxycodone 0.05 mg/kg, 0.1 mg/kg and 0.15 mg/kg were intravenously injected 15 min before anesthesia induction, and the control group was infused with equal volume of normal saline.The results showed that compared with T0, plasma concentrations of S-100, NSE and MDA increased and SOD concentrations decreased in each group at T1-T4. Compared with the control group, plasma S-100 in Q1-Q3 group at T1-T4 time. The concentration of sputum, NSE and MDA decreased, and the concentration of SOD increased, indicating that oxycodone can reduce the lipid peroxidation induced by oxygen free radicals and effectively enhance the ability of CPB patients to scavenge oxygen free radicals. And S-100 prion protein and NSE concentration were negatively correlated with SOD activity.Conclusion: Oxycodone preconditioning can alleviate brain damage in patients with carotid endarterectomy under CPB, and its mechanism may be related to inhibition of brain lipid peroxidation.