Clinical Effect of Metoprolol in the Treatment of Septic Shock Complicated with Myocardial Injury

  • Rui Zhang
Keywords: Metoprolol; Septic shock; Myocardial injury; Hemodynamics

Abstract

Septic shock is a clinical syndrome characterized by organ dysfunction caused by systemic infection, which is the main cause of death in critically ill patients. The clinical effects of metoprolol in the treatment of septic shock with myocardial injury were analyzed. The heart rate was reduced by 20% by intravenous metoprolol injection and maintained for 6 hours. The hemodynamics and oxygen metabolism parameters were collected dynamically and continuously to establish a database. Heart rate and cardiac output index decreased significantly after administration (P < 0.05). There was no significant difference in oxygen saturation of mixed venous blood before and after treatment (P > 0.05). In conclusion, metoprolol can safely and effectively reduce heart rate and cardiac output in patients with myocardial injury in the early stage of septic shock, without deteriorating hemodynamics and oxygen metabolism. It has great potential in treating septic shock and improving prognosis. In addition, the optimal timing, dosage, duration, adverse cardiovascular events, short-term and long-term prognosis of metoprolol should be further studied.

Published
2019-10-01