Effect of Different Doses of Dexmedetomidine combined with Flurbiprofen Axetil and Butorphanol on Patients undergoing Radical Operation for Open Bowel Tumors

  • Chunxia Zhu
Keywords: Dexmedetomidine; flurbiprofen ester; Butorphanol; Gastrointestinal tumors; Analgesic effect


This paper investigates the efficacy of different doses of dexmedetomidine (DEX) mixed with flurbiprofen and butorphanol in patients undergoing radical surgery for open abdominal tumors. Compared with the control group, the VAS scores of TEX2 and DEX3 were significantly decreased at T1, T2 and T3 (P<0.05), and the Ramsay scores at T2 and T3 were significantly increased (P<0.05). Compared with DEX1, DEX2 The VAS scores of T2 and T3 were significantly lower in the group and DEX3 groups (P<0.05), and the Ramsay scores were significantly higher (P<0.05). No respiratory depression, bradycardia, sedation and hypotension occurred in the four groups. Compared with the control group, the postoperative analgesic remediation rate was significantly decreased in the DEX2 group and the DEX3 group (P<0.05), and the incidence of postoperative sleepiness was significantly increased in the DEX3 group (P<0.05). The satisfaction rates of DEX1 group, DEX2 group, DEX3 group and control group were 70%, 90%, 90%, and 70%, respectively. The satisfaction of the four groups was significantly different (P<0.001); the satisfaction of DEX2 and DEX3 groups was satisfactory. The difference was statistically significant compared with the control group (P<0.05). 2μg/kg and 3μg/kg DEX mixed flurbiprofen and butorphanol were effective in the treatment of open bowel tumors. The adverse reactions were less, but the best effect of 2μg/kg DEX was more suitable. Postoperative analgesia in patients undergoing radical surgery for open abdominal tumors.