Expression Relationship of T-lymphocyte Subsets and the Viral Load in Peripheral Blood of HIV Infected alone and HIV Infected with HBV and HCV

  • Jinghua Zhang
Keywords: Human immunodeficiency virus; Viral load; T lymphocyte subsets; Hepatitis B virus

Abstract

This paper explores the relationship between the viral load of peripheral blood and the expression of T-lymphocyte subsets in patients with HIV infection alone and HIV combined with HBV and HCV infection.64 HIV positive patients in our hospital were selected as the research objects, and divided into three groups according to the patients' combined infection. Group A (n = 22) was infected with HIV, group B (n = 21) was infected with HBV, and group C (n = 21) was infected with HCV. There were significant differences in alt, AST, TBIL and DBIL levels among the three groups (P < 0.05). In terms of HIV RNA expression, group A was significantly less than group B and group C (P < 0.05), and there was no significant difference between group B and group C (P > 0.05); in terms of T-lymphocyte subsets, CD4+ and CD8+ in group B were significantly lower than those in group A (P < 0.05), CD4+ was significantly lower than those in group C (P < 0.05), and in terms of CD4+ / CD8+ comparison, there was no significant difference among the three groups (P > 0.05). The correlation between HIV RNA and T lymphocyte was significant (P < 0.05). There was a negative correlation between the expression of T lymphocyte subsets and the viral load in peripheral blood of HIV infected alone and HIV infected with HBV or HCV.

Published
2020-01-01