Clinical Research Progress of Preterm Necrotizing Enterocolitis in Recent Years

  • Li Qian
Keywords: Necrotizing enterocolitis; Intensive care;Serum IL-33; fecal calcium protective protein


Necrotizing enterocolitis (NEC) in premature infants has long remained one of the most common critical diseases in neonatal intensive care unit (NICU). The disease has a hidden onset, rapid progress and a high mortality and disability rate, but its etiology and pathogenesis is complex, which is still the focus of attention in neonatology. The etiology and pathogenesis of NEC is complex. In recent years, it has been found that plasma MIR-1290, serum IL-33, endothelin, fecal calcium protective protein, blood/ urine and intestinal fatty acid binding protein, near-infrared spectroscopy and intestinal ultrasonography are all helpful for the early diagnosis of NEC. Probiotics, breast milk and lactoferrin may have some preventive effects on NEC. The content of DSLNT in breast milk can be used to screen out high-risk feeding milk. Stem cell therapy may provide new research directions to improve the prognosis.