Topiramate in Children with Epilepsy and Its Symptom Control and EEG Improvement

  • Yuan Zhang
Keywords: Children with epilepsy; Cognitive function; Sodium valproate; Topiramate; EEG discharge index

Abstract

Epilepsy is a chronic brain disease characterized by sudden, repetitive and transient central nervous system dysfunction caused by supersynchronous abnormal discharge of brain neurons. It is a common neurological clinical syndrome in children. This article was to observe the effect of topiramate and EEG discharge index on cognitive function in children with epilepsy. To observe the changes of cognitive function in children with epilepsy after 6 months of TPM and VPA treatment, and to explore the cognitive function of children with EEG discharge index greater than or equal to 0.5 and EEG discharge index less than 0.5. After treatment, the visual spatial function, naming ability, computational power, language ability, abstract ability, orientation power and delayed recall ability score of the children in the VPA group did not change significantly (P>0.05), while the scores of the children in the TPM group were significantly higher. Decrease (P<0.05). Children with EEG discharge index less than 0.5 had visual space function, naming ability, computational power, language ability, abstract ability, orientation power and delayed recall ability score higher than those with a brain discharge index greater than or equal to 0.5. The treatment of children with epilepsy with valproic acid had no obvious adverse reactions to cognitive function, while topiramate had certain damage to the cognitive function of children, and valproic acid was safer. The cognitive function of children with epilepsy is closely related to the EEG discharge index. EEG should be monitored regularly during the clinical treatment of epilepsy.

Published
2020-03-01