Effect of Dexmedetomidine on Lung Injury Factors in Patients with Lung Injury during Perioperative Mechanical Ventilation

  • Benwang Zhang
Keywords: Dexmedetomidine; ARDS; Mechanical ventilation; Inflammatory factors; Lung injury


The effect of dexmedetomidine on inflammatory factors and lung injury in patients with ARDS was studied. For ARDS patients, on the basis of the treatment of the primary disease, mechanical ventilation was used for lung protective ventilation strategy. During the treatment, the balance of inflammatory factors and the reduction of stress response are beneficial to the prognosis of patients. IL 6, IL 8 and IL 10 can be increased during stress, and the reduction of stress can inhibit the production of inflammatory factors. The results showed that compared with T0, the concentrations of IL 6, IL 8 and IL 10 in T1-T4 group were significantly higher (P < 0.05), PaO2 / fio2t2-t4 in D group were significantly higher (P < 0.05), T1-T4 in C group were significantly lower (P < 0.05), HR in T1-T4 group was lower in D group and higher in C group (P < 0.05). Compared with group C, IL-6, IL-8, PaO2 / FiO2, HR and map in group D were significantly lower in T2-T4, higher in T2-T4 and T1-T4, respectively (P < 0.05). Dexmedetomidine can balance the release of inflammatory factors and reduce lung injury in ARDS patients.