Therapeutic Effect of Cefazolin Pentahydrate on Open Fracture of Limbs with Soft Tissue Injury after Operation

  • Zhaopeng Xuan
Keywords: Cefazolin sodium pentahydrate; Open fracture; Soft tissue injury; Wound infection

Abstract

Cefazolin pentahydrate is an improved single crystal chelating structure based on cefazolin sodium. It has high affinity with penicillin binding protein of cell membrane, and can induce the acylation of transpeptidase, thus inhibiting the growth of bacteria. This paper analyzed the effect of cefazolin sodium pentahydrate in the treatment of severe open fracture of extremities with soft tissue injury and wound infection after operation. After operation, the wounds of the two groups were treated routinely. On this basis, cefazolin sodium and cefazolin sodium pentahydrate were used to treat the patients in the control group and the observation group respectively, and then the MC gill score and the postoperative infection control time of the two groups were compared. After treatment, the MC gill score of the observation group was lower than that of the control group, and the time of postoperative infection control was shorter than that of the control group. Using cefazolin pentahydrate to treat severe open fractures of extremities with soft tissue injury and wound infection after operation can significantly reduce the pain of wound and shorten the time of infection control after operation.

Published
2020-03-01