Relationship Between the Protective Effect of Vasoactive Peptide on Diabetic Cardiomyopathy and Aktgsk-3 β Signal Pathway

  • Kun Tang
Keywords: Urocortin; Diabetic cardiomyopathy; Transforming growth factor-β1; Akt; Glycogen synthetase kinase 3β

Abstract

In this paper, the effects of urocortin (Ucn) on TGF β 1 and CTGF in diabetic cardiomyopathy (DCM) rats were observed. Wnt / β - Catenin and NF - κ B signaling pathway are considered to be important signaling pathways for the development of diabetes mellitus, which play an important role in the metabolism of cells and play an important role in various life activities of cells. Results compared with the control group, the levels of TGF - β 1 and CTGF in serum and myocardium were increased, and p-Akt and p-gsk-3 β in myocardium were decreased in DCM group. Compared with DCM group, the levels of TGF - β 1 and CTGF in Ucn group were lower, astrissin and triciribine could block the effect of UCN, p-Akt and p-gsk-3 β in Ucn group were higher, and astrissin blocked the effect of UCN The protective effect of UCN on DCM may be related to the activation of Akt / GSK-3 β signaling pathway and the down regulation of TGF - β 1 and CTGF expression after binding with CRH-R receptor.

Published
2020-03-01