Pharmacological Mechanism of Omeprazole and the Safety and Adverse Reactions of Clinical Nurses

  • Lixia Deng
Keywords: Omeprazole sodium for injection; Nursing staff; Drug risk; Adverse drug cognition


Omeprazole sodium for injection is a kind of benzimidazole compound, which is a kind of weak alkaline substance. Its compatibility stability is affected by pH value, light, metal ions, temperature and other factors. This paper analyzed the risk identification ability of nurses for omeprazole sodium for injection, strengthened the risk management of drugs in the ward, and provided reference for the safety of patients. In 2016 and 2018, the self-designed questionnaire was used to investigate and analyze the knowledge about the risk of omeprazole sodium injection among the nurses in the emergency department, digestive department, ICU and CCU of the hospital. The results showed that 100% of the nurses interviewed in the two surveys were able to select at least one solvent correctly, accounting for 2% and 4% respectively; the correct rate of response to the infusion time of the drug was 95% and 97% respectively; the proportion of clinical adverse reactions encountered was 28% and 15% respectively; the proportion of clinical improper compatibility with other injections was 8% and 25%, and the drugs with the most improper times were 8% and 25%, respectively It is ornidazole sodium chloride injection, and the proportion of those who want to strengthen the continuing education of medical and nursing personnel is more than 45%. It is suggested that hospitals should strengthen the construction of drug risk management system, nurses should strengthen the study of drug risk knowledge, and play the role of clinical pharmacists in drug risk management, so as to reduce the related drug risk and the occurrence of adverse drug events.