Different Administration of Dexamethasone in the Treatment of Secretory Otitis Media
The efficacy and safety of dexamethasone in the treatment of chronic secretory otitis media were compared. The patients in the observation group were given dexamethasone sodium phosphate injection 5mg through eustachian tube under endoscope. The total effective rate of the observation group (93.33%) was significantly higher than that of the control group (80.00%), and the recurrence rate and the incidence of tympanic effusion were significantly lower than that of the control group (P < 0.05). Before treatment, there was no significant difference in bone conduction threshold, aquaporin 1 and aquaporin 4 levels between the two groups (P > 0.05). After treatment, the bone conduction threshold level of each frequency in the two groups was significantly lower than that before treatment in the same group, and the level of aquaporin 1 and aquaporin 4 in the observation group was significantly higher than that before treatment in the same group, and the difference was statistically significant (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: the treatment of chronic secretory otitis media with dexamethasone through eustachian tube under endoscopy is superior to that through tympanum puncture in terms of curative effect, clinical symptoms, bone conduction threshold of various frequencies, up-regulated expression of aquaporin, recurrence and risk of tympanum effusion, but the safety of the two methods is equivalent.