Relationship Between Serum Vitamin D Level and Depression in Patients with Polycystic Ovary Syndrome

  • Xiaoming Zhang
Keywords: Polycystic ovary syndrome; Depression; Vitamin D; Balance of phosphorus metabolism


PCOS is an endocrine disorder syndrome characterized by anovulation or anovulation, hyperandrogen or insulin resistance, and polycystic ovary. The relationship between serum vitamin D level and depression in patients with polycystic ovary syndrome (PCOS) was studied. BDI was used to evaluate whether PCOS patients had depression and the degree of depression. The serum 25 [OH] d level of 76 PCOS patients with depression was significantly lower than that of those without depression. There was a negative correlation between serum 25 [OH] D and BDI score (r = -0.341, P < 0.05). Serum 25 [OH] d predicted that the area under ROC curve of PCOS patients with depression was 0.924, and the best cutoff point was 11.5μg/l. The decrease of serum vitamin D level in patients with PCOS is closely related to depression. Vitamin D supplementation may provide a new way for the treatment of PCOS with depression.