Relationship Between Serum Vitamin D Level and Depression in Patients with Polycystic Ovary Syndrome
PCOS is an endocrine disorder syndrome characterized by anovulation or anovulation, hyperandrogen or insulin resistance, and polycystic ovary. The relationship between serum vitamin D level and depression in patients with polycystic ovary syndrome (PCOS) was studied. BDI was used to evaluate whether PCOS patients had depression and the degree of depression. The serum 25 [OH] d level of 76 PCOS patients with depression was significantly lower than that of those without depression. There was a negative correlation between serum 25 [OH] D and BDI score (r = -0.341, P < 0.05). Serum 25 [OH] d predicted that the area under ROC curve of PCOS patients with depression was 0.924, and the best cutoff point was 11.5μg/l. The decrease of serum vitamin D level in patients with PCOS is closely related to depression. Vitamin D supplementation may provide a new way for the treatment of PCOS with depression.