Research Progress of New Antitumor Drugs and Clinical Application of Fluorouracil

  • Yixuan Wang
Keywords: Fluorouracil; Cytotoxic drugs; Molecular targeted drugs; Tumor chemotherapy


Fluorouracil is one of the most widely used antitumor drugs in clinic. It can kill cancer cells by preventing the formation of pyrimidine nucleotides and interfering the synthesis of DNA. It is mainly used in the treatment of breast cancer, gastrointestinal cancer, ovarian cancer and primary bronchopulmonary adenocarcinoma. The main adverse reactions were gastrointestinal reactions and myelosuppression. This paper reviews and analyzes the current situation of clinical application and new research progress of anti-tumor drugs in recent years. Traditional cytotoxic drugs, including alkylating agents, anti metabolism drugs, metal platinum drugs, anti-tumor hormone drugs and anti-tumor antibiotics, still have a certain position in clinical use due to their use value, but because of the limitations of their treatment and the risk of adverse reactions As a result, newly developed drugs, molecular targeted drugs and anti-tumor botanical drugs are gradually taking their place in some fields and becoming the first choice of treatment. With the continuous development of clinical application, new cancer treatment drugs, such as marine drugs, anti-tumor Chinese herbal medicine, will be further developed in the future.