Effect of Shenqifuzheng Injection Combined with Chemotherapy on Ovarian Cancer and the Level of Tumor Related Markers CA125 and B7-H4

  • Xuewen Sun
Keywords: Chemotherapy; Ovarian cancer; Efficacy; Immune function; Tumor marker; CA125; B7-H4

Abstract

To investigate the therapeutic effect of Shenqifuzheng injection combined with chemotherapy on ovarian cancer and its influence on immune function and tumor related markers CA125 and B7-H4. Total effective rate of the observation group (62.00%) was higher than that of the control group (38.00%), the difference between the two groups was statistically significant (P <0.05); before treatment, there was no significant difference between the two groups in environmental, social, physiological and psychological quality of life scores and the total scores (P>0.05). After treatment, the scores of environment, society, physiology and psychology and the total scores of the two groups were significantly higher than those before treatment, the difference was statistically significant (P<0.05), and the scores of each field and the total scores of the observation group were significantly higher than those of the control group, the difference was statistically significant (P < 0.05); there was no statistical significance between the two groups in the comparison of CD3 +, CD4 +, and CD4 + / CD8 + before treatment (P > 0.05) . After treatment, CD3 +, CD4 + and CD4 + / CD8 + were increased in the two groups, and CD3 +, CD4 + and CD4 + / CD8 + in the observation group were higher than those in the control group, the difference was statistically significant (P<0.05); before treatment, CA125, B7-H4 and levels in the two groups were not statistically significant (P>0.05). The levels of CA125 and B7-H4 in the observation group were lower than those in the control group (P<0.05). Conclusion: Shenqifuzheng injection combined with chemotherapy is effective in the treatment of ovarian cancer, it can enhance the immune function of patients, reduce the levels of serum tumor markers CA199, CEA and CA125, and has little adverse reactions, which is of great significance.

Published
2020-03-01