Clinical Effect of Ginsenoside Rb1 on Anti-depression and Other Psychological Diseases

  • Yun Wang
Keywords: Depression; Ginsenoside Rb1; Animal behavior; Pharmacological analysis


To observe the behavioral changes of animals after Ginsenoside Rb1 was administered, and to explore the antidepressant effect of Ginsenoside Rb1. After giving different doses of ginsenoside Rb1 to rats, tail suspension test (TST) and forced swimming test (FST) were conducted to observe the effects of ginsenoside Rb1 on immobility time of mice, and the effects of ginsenoside Rb1 on immobility time and immobility latency of rats were observed by FST. Sexual moderate stress (CMS) model was established. Open-box experiments and sugar preference experiments were conducted regularly. The results showed that ginsenoside Rb1 decreased the immobility time of animals in desperate state in a dose-dependent manner, and prolonged the incubation period of immobility in rats. The difference was statistically significant compared with the blank group (P < 0.05). Chronic moderate stress gradually reduced the autonomous activity of rats, the detection behavior of novelty environment and the preference for sugar water. Ginsenoside Rb1 had a slowing effect on it, which had statistical significance compared with CMS group (P < 0.05). Ginsenoside Rb1 has obvious antidepressant effect on animal behavior.