Effect of Serum Carcinoembryonic Antigen Expression Level on Chemotherapy Efficacy in Patients with Advanced Lung Adenocarcinoma

  • Yanming Li
Keywords: Serum carcinoembryonic antigen; Advanced lung adenocarcinoma; Positive; Chemotherapy effect

Abstract

To investigate the effect of serum carcinoembryonic antigen (CEA) expression levels on the efficacy of
chemotherapy in patients with advanced lung adenocarcinoma. 102 patients with advanced lung
adenocarcinoma treated in our hospital from June 2017 to August 2018 were selected as the main subjects.
According to the results of CEA, 50 patients were divided into positive group and 52 patients into negative
group. The factors affecting CEA expression in serum of the two groups were compared and analyzed, and the
effects of these factors on the efficacy of chemotherapy were further analyzed. Smoking history was an
independent factor affecting the expression level of CEA in patients with advanced lung adenocarcinoma
(χ2=4.708, P<0.05). After 4 weeks of treatment, the recent control rate was 84.00% in the positive group and
66.67% in the negative group. The difference was statistically significant (χ2=6.457, P<0.05). The mean and
median progression-free survival were positive in the positive group. The difference was statistically significant
(t=13.206, P<0.05). When the serum CEA expression level is positive in patients with advanced lung
adenocarcinoma, the effect of chemotherapy is better.

Published
2020-05-01