Relationship between Serum Prealbumin Levels and Levels of Inflammatory Factors and Myocardial Enzymes in Patients with Acute Myocardial Infarction

  • Heng Niu
Keywords: Acute myocardial infarction; Prealbumin; Inflammatory factor; Myocardial enzyme

Abstract

To study the relationship between serum prealbumin levels and levels of inflammatory factors and myocardial
enzymes in patients with acute myocardial infarction. Comparing the levels of serum PA, inflammatory factors
and myocardial enzymes in patients with acute myocardial infarction and healthy controls, we found a
significant decrease in serum prealbumin in the study group, hs-CRP, hs-cTnT, IL- 6. The level of indicators
such as IL-8 and CK-MB has increased significantly. Data comparison P < 0.05, statistically significant.
Pearson correlation analysis showed that the relationship between serum PA and hs-CRP, IL-6, IL-8 and other
indicators was negatively correlated. The r values were -0.562, -0.591, -0.548, respectively. There was no
significant correlation between P<0.05l and hs-cTnT and CK-MB results. The r-value results showed -0.018, -
0.149, respectively, and the data comparison was P>0.05. The ROC curve analysis showed that the area under
the ROC curve for the diagnosis of acute myocardial infarction by serum prealbumin was 0.783±0.039, which
indicated that the 95% confidence interval (95% CI) was 0.706-0.860. P < 0.05, which was statistically
significant. When the PA cutoff value was 0.190 g/L, the predicted AMI sensitivity was 29.64% and the
specificity was 62.23%. Serum prealbumin levels in patients with myocardial infarction have decreased
significantly. The levels of inflammatory factors and myocardial enzymes are significantly higher than those in
healthy people. This result suggests that we have inflammatory response in patients with myocardial infarction.
Once activated, serum prealbumin is likely to participate in the AMI inflammatory response process, which has
a certain promoting effect on disease monitoring.

Published
2020-05-01