Effect of Simvastatin combined with Aspirin on Diabetic Renal Microangiopathy and Influence on Patients’ Internal Environment

  • Liping Chen
Keywords: Simvastatin; Renal microangiopathy; Diabetes; Aspirin

Abstract

To investigate the effect of simvastatin combined with aspirin on diabetic renal microangiopathy and its effects
on P-selectin, TNF-α, hs-CRP, IL-1β and ICAM. Observed blood lipid index, inflammatory factors, coronary
heart disease, hypertension, acute myocardial infarction. The blood lipid levels of the combined treatment group
decreased before and after treatment (P<0.05). The decrease of blood lipids in the combined treatment group
was significantly higher than that of the control group (both P<0.05). The combination treatment group Pselectin,
TNF-α, hs-CRP, IL-1β, and ICAM levels were decreased before and after treatment (all P<0.05). Pselectin
and TNF- after treatment in the combination group. The decrease of α, hs-CRP, IL-1β and ICAM levels
was significantly higher than that of the control group (P<0.05). The incidence of coronary heart disease and
hypertension in the combined treatment group was much less than that of the control group (χ2 =4.853, 6.346, P
<0.05). The control effect and control degree of blood lipid, P-selectin, TNF-α, hs-CRP, IL-1β, ICAM and
complications in the treatment group treated with simvastatin and aspirin are better than those of simple
treatment.

Published
2020-05-01