Inhibition of Diosgenin on Human Oral Squamous Cell Carcinoma

  • Lei Shi
Keywords: Diosgenin; Candida albicans; Oral squamous cell carcinoma; Inhibition

Abstract

Diosgenin, a steroidal saponin, is abundantly present in plants. This bioactive phytochemical is not only used as
an important raw material for the preparation of several steroids in the pharmaceutical industry, but also in the
treatment of various types of Diseases such as oral squamous cell carcinoma have great benefits. This study
aimed to investigate the inhibitory effect of diosgenin on human oral squamous cell carcinoma. Candida
albicans was extracted and extracted and analyzed to separate, detect and quantify dioscin, not only in natural
sources and pharmaceutical compositions. Among them, high performance liquid chromatography coupled with
different detectors is the most commonly used analytical method. Within 4 hours, the concentration of diosgenin
ranged from 1-4 μ g/mL inhibited biofilm formation by 10% to 80%. After 4 hours, diosgenin began to recover,
indicating a short-term fungicidal effect. Dioscin may be a candidate for the treatment of oral squamous cell
carcinoma.

Published
2020-05-01