Study on the Relationship between LACT Methylation and Homocysteine in Atherosclerosis Patients

  • Jia Zhao
Keywords: Atherosclerosis; LACT methylation; Homocysteine


Cardiovascular risk and plasma total homocysteine (tHcy) are high in patients with renal failure. High tHcy may
be the main reason for the increased risk. We investigated the relationship between LACT methylation and
homocysteine in patients with atherosclerosis. Ultrasound was used to detect TPA and carotid stenosis. After
adjusting for factors such as age, gender, systolic blood pressure (SBP), smoking, low-density lipoprotein (LDL),
high-density lipoprotein (HDL), and body weight, multiple linear regression was used to analyze the effects of
eGFR and / or tHcy. eGFR decreased, and TPA and total stenosis increased linearly with age. After adjustment
[age, gender, SBP, smoking, low-density lipoprotein (LDL), high-density lipoprotein (HDL), weight, eGFR, and
tHcy were independently related to TPA (P <0.01), but all were significant after adding the model Reduction (P
= 0.06, tHcy is 0.03). Intermediate analysis shows that tHcy seems to play an important mediating role in the
relationship between eGFR and TPA, but has no effect on stenosis. After adjustment by the above risk factors,
tHcy still has a significant regulating effect on TPA (P = 0.03), and has no significant effect on stenosis.
Regulatory effect (P = 0.16). tHcy plays an important role in atherosclerosis, but not all. Other uremic toxins,
including metabolites of the intestinal flora may explain the residual effects of renal failure on atherosclerosis.
The treatment methods based on this assumption are discussed.