Contribution of heterogeneity in cell signaling to clinical course for patients with sepsis

  • Xabier Marin
Keywords: Cell signaling, accidental trauma, proinflammatory effects, bacteria, fungi, and viruses


Multiple intracellular signaling pathways involving kinases, transcriptional factors, and the expression of
immunoregulatory mediators are altered in cell populations that contribute to organ system dysfunction and
mortality in sepsis. Activation of such intracellular events is initiated by interaction of microbial products with Tolllike
receptors and other receptors, including G protein–coupled receptors.