Correlation Analysis of CPN, Hp, HCMV Pathogenic Microorganism Infection Status And Serum Inflammation Marker Level in Patients with Coronary Heart Disease

  • Zhifeng Yao
Keywords: Coronary heart disease; CPN; Hp; HCMV; Serum inflammation markers

Abstract

To investigate the correlation between CPN, Hp, HCMV pathogenic microorganism infection status and serum
inflammation marker levels in patients with coronary heart disease. The CPN-IgG single positive rate, Hp-IgG
single positive rate, HCMV-IgG single positive rate, double positive rate and triple positive rate in the
observation group were 10.0%, 14.3%, 18.6%, 41.4% and 11.4%, respectively. , Are significantly higher than
the control group, and the difference between the groups is statistically significant (P<0.05); interleukin-6,
hypersensitive C-reactive protein and tumor necrosis factor-α in three positive patients are (37.4±8.9) pg/ml,
(15.1±3.2) mg/L and (36.2±8.6) ng/L, significantly higher than the levels of serum inflammation markers
corresponding to double-positive, single-positive and full-negative patients, the difference is statistically
significant Significance (P<0.05); serum inflammatory markers of double-positive patients were significantly
higher than those of single-positive patients, the difference was statistically significant (P<0.05); serum
inflammatory markers of single-positive patients The level of substance was significantly higher than that of
serum inflammation markers corresponding to all negative patients, and the difference was statistically
significant (P<0.05). The infection load of CPN, Hp and HCMV pathogenic microorganisms in patients with
coronary heart disease is positively correlated with the level of serum inflammation markers, which is closely
related to the incidence of coronary heart disease. The mixed infection of three pathogenic microorganisms can
enhance the inflammatory response of patients by inducing inflammation The reaction causes the occurrence
and development of the disease, and the more complicated the pathogenic microbial infection of the patient, the
higher the level of inflammation markers of the patient.

Published
2020-05-01