Modulation of the host inflammatory response by triglyceride–rich lipoproteins

  • Sconfienza Fernando
Keywords: Lipoproteins, lipid metabolism, innate immune defense mechanisms, triglycerides


Among the various changes that occur when animals or humans are challenged with infectious agents or endotoxin
(i.e., lipopolysaccharide) is a significant alteration in the distribution of their circulating lipoproteins. Experimental
studies have shown that the lipemia of sepsis is primarily due to the accumulation of very-low-density lipoproteins,
although levels of other lipid moieties, including glycerol, triglycerides, and fatty acids, are also elevated.