Association between macrophage migration inhibitory factor gene polymorphisms and inflammatory diseases

  • Loreto Jorge
Keywords: Inflammatory Diseases, innate immune system, microbial pathogens, macrophages


The innate immune system assumes an essential role in the natural host defenses against microbes. Sensing of
microbial pathogens, either in tissue in contact with the host’s environment or in the systemic circulation after
invasion of the bloodstream, is carried out by macrophages, dendritic cells, natural killer cells, granulocytes, and
monocytes acting as sentinels of the innate immune system.