Role of Carbapenems in the management of severe hospital-acquired infections

  • Marcia Lanari
Keywords: Carbapenems, gram-negative genera, Acinetobacter, Pseudomonas aeruginosa, plasmid


Carbapenems are important therapeutic agents for the treatment of infection with multidrug-resistant gramnegative
bacteria, particularly those carrying genes for extended-spectrum and derepressed AmpC b-lactamases. Of the blactams,
carbapenems have the broadest spectrum and greatest stability against hydrolysis by blactamases.